New approaches for testing non-inferiority for three-arm trials with Poisson distributed outcomes.

With the availability of limited resources, innovation for improved statistical method for the design and analysis of randomized controlled trials (RCTs) is of paramount importance for newer and better treatment discovery for any therapeutic area.
Although clinical efficacy is almost always the primary evaluating criteria to measure any beneficial effect of a treatment, there are several important other factors (e.g., side effects, cost burden, less debilitating, less intensive, etc.), which can permit some less efficacious treatment options favorable to a subgroup of patients. This leads to non-inferiority (NI) testing.
The objective of NI trial is to show that an experimental treatment is not worse than an active reference treatment by more than a pre-specified margin.
Traditional NI trials do not include a placebo arm for ethical reason; however, this necessitates stringent and often unverifiable assumptions. On the other hand, three-arm NI trials consisting of placebo, reference, and experimental treatment, can simultaneously test the superiority of the reference over placebo and NI of experimental treatment over the reference.
In this article, we proposed both novel Frequentist and Bayesian procedures for testing NI in the three-arm trial with Poisson distributed count outcome. RCTs with count data as the primary outcome are quite common in various disease areas such as lesion count in cancer trials, relapses in multiple sclerosis, dermatology, neurology, cardiovascular research, adverse event count, etc.

VX-661

A2664-5.1 10 mM (in 1mL DMSO)
EUR 183.00
Description: VX-661, one of vertex derivatives, corrects F508del-CFTR trafficking and increases F508del-CFTR protein activity in vitro [1]. VX-661 treated alone or in combination with ivacaftor have shown to enhance F508del-CFTR traf?cking to the cell surface. VX-661 has been at phase 2 study [1].

VX-661

A2664-50 50 mg
EUR 560.00
Description: VX-661, one of vertex derivatives, corrects F508del-CFTR trafficking and increases F508del-CFTR protein activity in vitro [1]. VX-661 treated alone or in combination with ivacaftor have shown to enhance F508del-CFTR traf?cking to the cell surface. VX-661 has been at phase 2 study [1].

VX-661

B1268-25
EUR 544.00

VX-661

B1268-5
EUR 175.00

miRZip-661 anti-miR-661 microRNA construct

MZIP661-PA-1 Bacterial Streak
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  • Category: MicroRNA Tools

hsa-miR-661 Primers

MPH01964 150 ul / 10 uM
EUR 121.00

p24-HIV(p24/661) Antibody

BNC810661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC810661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC880661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC880661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC940661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC940661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC800661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC800661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC400661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC400661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC470661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC470661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC430661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC430661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC550661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC550661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC700661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC700661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC680661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC680661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC610661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC610661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCA0661-250 250uL
EUR 383.00
Description: Primary antibody against p24-HIV(p24/661), APC conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCAP0661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCAP0661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCB0661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCB0661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC050661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC050661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC040661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC040661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNUM0661-50 50uL
EUR 395.00
Description: Primary antibody against p24-HIV(p24/661), 1mg/mL

p24-HIV(p24/661) Antibody

BNCP0661-250 250uL
EUR 383.00
Description: Primary antibody against p24-HIV(p24/661), PerCP conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCR0661-250 250uL
EUR 383.00
Description: Primary antibody against p24-HIV(p24/661), RPE conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCH0661-100 100uL
EUR 199.00
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCH0661-500 500uL
EUR 544.00
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNUB0661-100 100uL
EUR 209.00
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL

p24-HIV(p24/661) Antibody

BNUB0661-500 500uL
EUR 458.00
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL

hsa-miR-661 miRNA Antagomir

MNH03370 2 x 5.0 nmol
EUR 329.00

hsa-miR-661 miRNA Inhibitor

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Recombinant (E.Coli) Protein Kinase A Inactive holoenzyme type 1 alpha

RP-661 1 ug
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MAP Kinase Substrate; EGF-R (661-681)

5-01501 4 x 1mg Ask for price

Polyclonal MYOM2 / Myomesin 2 Antibody (aa612-661)

APR03243G 0.05ml
EUR 484.00
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYOM2 / Myomesin 2 (aa612-661). This antibody is tested and proven to work in the following applications:

Human pre-microRNA Expression Construct Lenti-miR-661

PMIRH661PA-1 Bacterial Streak
EUR 684.00
  • Category: MicroRNA Tools

Recombinant Treponema Pallidum tkt Protein (aa 1-661)

VAng-Cr0963-inquire inquire Ask for price
Description: Treponema Pallidum (strain Nichols) transketolase (tkt), recombinant protein.

Recombinant Clostridium Difficile fbp Protein (aa 1-661)

VAng-Lsx9156-inquire inquire Ask for price
Description: Clostridium Difficile (strain 630) Fructose-1,6-bisphosphatase class 3, recombinant protein.

Recombinant Mycobacterium Tuberculosis Rv0102 Protein (aa 1-661)

VAng-Yyj0176-1mgEcoli 1 mg (E. coli)
EUR 6731.00
Description: Mycobacterium Tuberculosis Uncharacterized protein Rv0102/MT0111 (Rv0102, MT0111), recombinant protein.

Recombinant Pichia pastoris SNX4 Protein (aa 1-661)

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Description: Pichia pastoris Sorting nexin-4 (SNX4), recombinant protein.

Recombinant Clostridium Tetani uvrB Protein (aa 1-661)

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Description: Clostridium Tetani UvrABC system protein B, recombinant protein.

Recombinant Brucella Abortus bhuA Protein (aa 1-661)

VAng-Lsx5157-inquire inquire Ask for price
Description: Brucella Abortus biovar 1 (strain 9-941) Heme transporter BhuA, recombinant protein.

Recombinant Brucella Suis bhuA Protein (aa 1-661)

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Description: Brucella Suis biovar 1 (strain 1330) Heme transporter BhuA, recombinant protein.

Recombinant Trypanosoma Brucei HSP70-4 Protein (aa 1-661)

VAng-Wyb8104-inquire inquire Ask for price
Description: Trypanosoma Brucei brucei Heat shock 70 kDa protein 4, partial, recombinant protein.

Recombinant HCV-1c E2 Protein (aa 384-661) [His]

VAng-Wyb7362-100g 100 µg
EUR 1747.00
Description: Hepatitis C virus (serotype 1c,isolate HC-G9) E2 protein, recombinant protein.

Recombinant HCV-1c E2 Protein (aa 384-661) [His]

VAng-Wyb7362-20g 20 µg
EUR 679.00
Description: Hepatitis C virus (serotype 1c,isolate HC-G9) E2 protein, recombinant protein.

Recombinant HCV-1c E2 Protein (aa 384-661) [His]

VAng-Wyb7362-50g 50 µg
EUR 1213.00
Description: Hepatitis C virus (serotype 1c,isolate HC-G9) E2 protein, recombinant protein.

Recombinant Caenorhabditis Elegans lst-2 Protein (aa 1-661)

VAng-Ly3528-inquire inquire Ask for price
Description: Caenorhabditis Elegans lateral signaling target protein 2 (lst-2), partial, recombination protein.

Anti-AFP (Tacatuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC

ADC-W-661 1mg Ask for price
Description: This ADC product is comprised of an anti-AFP monoclonal antibody conjugated via a MC-Vc-PAB-DMEA-(PEG2) linker to duocarmycin SA

Anti-Hu CD84 Purified

11-661-C025 0.025 mg
EUR 99.00

Anti-Hu CD84 Purified

11-661-C100 0.1 mg
EUR 158.00

Anti-Hu CD84 FITC

1F-661-T025 25 tests
EUR 122.00

Anti-Hu CD84 FITC

1F-661-T100 100 tests
EUR 204.00

Anti-Hu CD84 PE

1P-661-T025 25 tests
EUR 140.00

Anti-Hu CD84 PE

1P-661-T100 100 tests
EUR 240.00

Anti-Hu CD84 APC

1A-661-T025 25 tests
EUR 140.00

Anti-Hu CD84 APC

1A-661-T100 100 tests
EUR 240.00

Anti-Hu CD84 Purified Low Endotoxin

12-661-C100 0.1 mg
EUR 158.00

HIV type 1 Glycoprotein 140 (aa 37 - 661)(Du151) [His]

DAG2131 100 µg Ask for price

Recombinant Brucella Abortus bhuA Protein (strain 2308) (aa 1-661)

VAng-Lsx4953-inquire inquire Ask for price
Description: Brucella Abortus (strain 2308) Heme transporter BhuA, recombinant protein.

MAP Kinase Substrate; EGF-R (661-681) (AA: Lys-Arg-Glu-Leu-Val-Glu-Pro-Leu-Thr-Pro-Ser-Gly-Glu-Ala-Pro-Asn-Gln-Ala-Leu-Leu-Arg) (MW: 2318.66)

SP-101475-1 1 mg
EUR 164.00
We first propose an improved Frequentist approach, which is then followed by it’s Bayesian version. Bayesian methods have natural advantage in any active-control trials, including NI trial when substantial historical information is available for placebo and established reference treatment. In addition, we discuss sample size calculation and draw an interesting connection between the two paradigms.